Laboratory of Cancer Genetics

Selected Publication

Fu L, Qin YR, Ming X, Zuo XB, Diao YW, Zhang L, Ai J, Liu BL, Huang TX, Cao T, Tan BB, Xiang D, Zeng CM, Gong J, Zhang Q, Dong S, Chen J, Liu H, Wu JL, Qi RZ, Xie D, Wang LD, Guan X. RNA editing of SLC22A3 drives early tumor invasion and metastasis in familial esophageal cancer. Proceedings of the National Academy of Sciences, 2017, v. 114, p. E4631-4640; 10.1073/pnas.1703178114

Liu M, Chow KKR, Li Y, Guan X. CHD1L promotes lineage reversion of hepatocellular carcinoma through opening chromatin for key developmental transcription factors. Hepatology, 2016, v. 63 n. 5, p. 1544-1559; 10.1002/hep.28437

Ming XY, Fu L, Zhang LY, Qin YR, Cao TT, Chan KW, Ma S, Xie D, Guan XY. Inegrin α7 is a functional cancer stem cell surface marker in oesophageal squamous cell carcinoma. Nature Communication 2016; 10.1038/ncomms13568

Chen L, Li Y, Lin CH, Chan TH, Chow RK, Song Y, Liu M, Yuan YF, Fu L, Kong KL, Qi L, Li Y, Zhang N, Tong AH, Kwong DL, Man K, Lo CM, Lok S, Tenen DG, Guan XY. Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma. Nat Med. 2013;19(2):209-16.

Kong KL, Kwong DL, Fu L, Chan TH, Chen L, Liu H, Li Y, Zhu YH, Bi J, Qin YR, Law SY, Guan XY. Characterization of a candidate tumor suppressor gene uroplakin 1A in esophageal squamous cell carcinoma. Cancer Res. 2010; 70(21): 8832-41.


Awards and Achievement
Awards of Director
  1. 2009年度上海市自然科学奖一等奖：钦伦秀，叶青海，汤钊猷，王心伟，关新元，贾户亮，任宁，孙惠川，刘银坤，王鲁。《肝癌转移的分子基础与分子预测》。The First-class of Natural Science Prize of Shanghai, 2009.(Fig.1)
  2. 2010年度国家自然科学奖二等奖：钦伦秀，叶青海，汤钊猷，关新元，贾户亮。《肝癌转移机理的新发现及其意义》。The Second-class of National Prize for Natural Sciences of China, 2010. (Fig.2)
  3. 2010年度国家自然科学奖二等奖：钦伦秀，叶青海，汤钊猷，关新元，贾户亮。《肝癌转移机理的新发现及其意义》。The Second-class of National Prize for Natural Sciences of China, 2010. (Fig.2)
  4. Xin-Yuan Guan: 2012 Outstanding Research Award, The University of Hong Kong.
  5. 2012国家科技进步奖一等奖：卞修武，关新元，寿成超，江秉华，杨治华，林李家宓，彭红卫，方伟岗，娄晋宁，孔祥复，平轶芳，刘凌志，姚小红，余时沧，蒋雪峰。《肿瘤血管生成机制及其在抗血管生成治疗中的应用》。The First-class of National Prize for Progress in Science and Technology of China, 2012. (Fig.3)
  6. 2014年度高等学校科学研究优秀成果奖（自然科学二等奖）：关新元，陈蕾蕾，马桂宜，李妍，刘铭，马宁芳，胡亮，陈汉文。《肝癌发生发展的分子机制研究》。Science and Techology Prize of Higher Education of China (Natural Science, Second-class, 2014).
  7. Xin-Yuan Guan: Outstanding Research Student Supervisor Award 2015/2016, The University of Hong Kong.
Awards of Team Members
  1. Stephanie KY Ma, Li Ka Shing Prize for the Best Ph.D. Thesis, The University of Hong Kong (2006/2007).
  2. Stephanie KY Ma, Hong Kong Young Scientist Award (Lift Science Panel), Hong Kong Institution of Science (2008).
  3. Leilei Chen, YS and Christabel Lung Postgraduate Scholarship 2008/2009, The University of Hong Kong.
  4. Leilei Chen, YS and Christabel Lung Postgraduate Scholarship 2008/2009, The University of Hong Kong
  5. Leilei Chen, Hui Pun Hing Scholarship for Postgraduate Research at 2008/2009, The University of Hong Kong
  6. Leilei Chen, YS and Christabel Lung Postgraduate Scholarship 2009/2010, The University of Hong Kong
  7. Suisui Dong, YS and Christabel Lung Postgraduate Scholarship 2009/2010, The University of Hong Kong
  8. Leilei Chen, The Outstanding Presentation award in “14th Rsearch Postgraduate Symposium, The University of Hong Kong, 2009, Hong Kong
  9. Leilei Chen, Hong Kong Young Scientist Award (Honourable Mention, Lift Science Panel), Hong Kong Institution of Science (2010)
  10. Leilei Chen, Dr KP Stephen Chang Gold Medal for the Best Ph.DThesis, The University of Hong Kong (2009/2010)
  11. Leilei Chen, Li Ka Shing Prize for the Best Ph.D Thesis, The University of Hong Kong (2009/2010)
  12. Yangyang Song, 2010 University Postgraduate Fellowship, The University of Hong Kong
  13. Alissa M Wong, Sir Edward Youde Memorial Fellowship for the Year 2010/2011, Sir Edward Youde Memorial Fund Council
  14. Kar Lok Kong, YS and Christabel Lung Postgraduate Scholarship 2010/2011, The University of Hong Kong
  15. Kwan Ho Tang, YS and Christabel Lung Postgraduate Scholarship 2010/2011, The University of Hong Kong
  16. Alissa M Wong, The HKAUW Dr Thomas HC Cheung Postgraduate Scholarship 2011, Hong Kong Association of University Women
  17. Alissa M Wong, YS and Christabel Lung Postgraduate Scholarship 2011/2012, The University of Hong Kong
  18. Ming Liu, YS and Christabel Lung Postgraduate Scholarship 2011/2012, The University of Hong Kong
  19. Zhiyu Wang, YS and Christabel Lung Postgraduate Scholarship 2011/2012, The University of Hong Kong
  20. Man Tong, Wong Ching Yee Medical Postgraduate Scholarship 2011/2012, The University of Hong Kong
  21. Ming Liu, YS and Christabel Lung Postgraduate Scholarship 2012/2013, The University of Hong Kong
  22. Man Tong, Wong Ching Yee Medical Postgraduate Scholarship 2012/2013, The University of Hong Kong
  23. Juan Chen, Wong Ching Yee Medical Postgraduate Scholarship 2012/2013, The University of Hong Kong
  24. Alissa M Wong, Wong Ching Yee Medical Postgraduate Scholarship 2012/2013, The University of Hong Kong
Press Release & Media Coverage
  1. Apple Daily,  January 29, 2013
    http://hk.apple.nextmedia.com/news/art/20130129/18149736
  2. HKU Press Releases,  January 29, 2013
    http://www.hku.hk/press/news_detail_9159.html
  3. Hong Kong Commercial Daily,  January 29, 2013
    http://www.hkcd.com.hk/pdf/201301/0129/HZ13129CLAA.Pdf
  4. Metropolis Daily,  January 29, 2013
    http://www.metrohk.com.hk/index.php?cmd=detail&id=204285
  5. Sing Pao, January 29, 2013
    http://www.singpao.com/xw/gat/201302/t20130224_420508.html
  6. Wen Wei Po,  January 29, 2013
    http://paper.wenweipo.com/2013/01/29/HK1301290044.htm